Selectins and their ligands: current concepts and controversies

Selectins and their ligands: current concepts and controversies.

Targeting Selectins and Their Ligands in Cancer

Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and vascular dissemination, leading to metastases. Hypersialylation of cancer cells is largely the result of ...

Current Concepts and Controversies in Orthopaedic Oncology

The manuscripts in this thematic issue on musculoskeletal oncology present different techniques and address difficult topics that have received limited attention in the current literature. Because of the wide variety of clinical situations encountered with bone and soft tissue tumors, it is essential for oncologic surgeons to be both facile and versatile. The following manuscripts contain valua...

Shoulder Instability. Current Concepts and Controversies

Early onset scoliosis: current concepts and controversies.

Early Onset Scoliosis (EOS) may be associated with long-term pulmonary morbidity, which is not commonly seen in Adolescent Idiopathic Scoliosis. Initial evaluation is based on determining any underlying etiology related to congenital or syndromic conditions. Assessing the impact of scoliosis on thoracic development may help guide treatment, which is often required at a young age in these childr...